Lisdexamfetamine: Side Effects, Dosage, Usage, and More (2023)

Lisdexamfetamine Highlights

Lisdexamfetamine oral capsule is only available as a brand name drug.Brand Name: Vyvanse
Lisdexamfetamine comes in two forms: an oral capsule and a chewable oral tablet.
Lisdexamfetamine oral capsules are used to treat attention deficit hyperactivity disorder (ADHD) and binge eating disorder (BED).

important warnings

FDA Warning: Abuse and Addiction

This medication has a black box warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box alert alerts doctors and patients to the potentially dangerous effects of medications.
Lisdexamfetamine has a high potential for abuse and addiction. Your doctor will discuss the risk with you before prescribing this medicine. You will be monitored for signs of abuse and addiction while you are using this medication.

other warnings

Heart problem warning:This drug may cause a stroke, heart attack, or sudden death in adults with or without heart problems. It can cause sudden death in children and adolescents with pre-existing heart problems or defects. Tell your doctor if you have heart problems, heart defects, or a family history of these problems. This medicine can also increase your blood pressure and heart rate. Tell your doctor if you have problems with your blood pressure or heart rate. Your doctor will monitor you for these conditions.
Mental health warning:If you have a mental illness, this medicine may make your symptoms worse. It can also cause psychotic or manic symptoms in children and adolescents with no history of these problems. You may have symptoms such as seeing, hearing, or believing things that are not real, or being suspicious. Tell your doctor if you have a mental health problem or a family history of suicide, bipolar disorder, or depression. Call your doctor right away if you have new or worsening mental symptoms.
Warning of circulatory problems:This medicine can cause poor circulation in the fingers and toes. Tell your doctor right away if you have numbness, pain, skin discoloration, temperature sensitivity, or unexplained sores on your fingers or toes.

What is lisdexamfetamine?

Lisdexamfetamine is a prescription medication. It comes as an oral capsule and as a chewable oral tablet.

Lisdexamfetamine oral capsule is only available as a brand name drug.Wyvanse. There is no generic version.

Lisdexamfetamine is acontrolled substance. It can be abused and its use can lead todependence. Selling or giving away may harm others and is illegal.

Because it is used

Lisdexamfetamine is used for treatmentAttention Deficit Hyperactivity Disorder (ADHD)and moderate to severeBinge Eating Disorder (BED).

This medication is not intended for weight loss. It is not known if it is safe and effective for treating obesity.

How does it work

Lisdexamfetamine belongs to a class of drugs called amphetamines. A drug class is a group of drugs that work in a similar way. These drugs are often used to treat similar conditions.

Lisdexamfetamine works by increasing the levels of certain brain chemicals. This helps improve concentration and focus and reduces hyperactivity and impulsivity.

side effects of lisdexamfetamine

Lisdexamfetamine oral capsule does not cause drowsiness, but it may cause other side effects.

Most Common Side Effects

Some of the more common side effects that can occur with lisdexamfetamine in the treatment of ADHD include:

distress
decreased appetite
Diarrhea
dizziness
dry mouth
irritability
nausea
sleep disorders
epigastric pain
To vomit
weightloss

Some of the more common side effects that can occur with lisdexamfetamine in the treatment of BES include:

dry mouth
sleep disorders
decreased appetite
increased pulse
constipation
feeling nervous
distress

If these effects are mild, they may go away in a few days to a few weeks.

If they get worse or do not go away, talk to your doctor or pharmacist.

serious side effects

Call your doctor right away if you have serious side effects.

Call 911 if your symptoms are life-threatening or if you think you have a medical emergency.

Lisdexamfetamine may interact with other medications

Lisdexamfetamine oral capsule can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or stop the medicine from working as well.

To avoid interactions, your doctor must carefully manage all your medications. Be sure to tell your doctor about all medicines, vitamins, or herbs you are taking. To find out how this medicine might interact with something else you are taking, talk to your doctor or pharmacist.

Examples of drugs that can cause interactions with lisdexamfetamine are listed below.

Tricyclic antidepressants (TCAs)

Using TCA with lisdexamfetamine can cause high levels of amphetamine in the brain. This could cause heart problems. The use of TCA with lisdexamfetamine may also increase the effects of lisdexamfetamine.

If you are taking lisdexamfetamine with an TCA, your doctor may adjust your dose of lisdexamfetamine. Or they may switch you to a different drug.

Examples of TCA are:

amitriptyline
desipramin
imipramine
property line

Monoamine oxidase inhibitor (MAO inhibitor)

Using MAOIs with lisdexamfetamine can cause extremely high blood pressure, which can lead to serious problems. You should not take this medicine with MAOIs or within 14 days of stopping MAOI treatment. Examples of MAO inhibitors are:

isocarboxazid
fennel
tranylcypromine
selegilina

Drugs that acidify urine

Taking these drugs with lisdexamfetamine can decrease the amount of time lisdexamfetamine stays in your body. This makes it less effective. Your doctor may need to adjust your dose of lisdexamfetamine if you are taking this type of medicine.

Examples of these drugs are:

ascorbic acid

Medications that alkalize urine

Taking these medicines with lisdexamfetamine can increase the time lisdexamfetamine stays in your body. This increases the effects of lisdexamfetamine. Your doctor may need to adjust your dose of lisdexamfetamine if you are taking this type of medicine.

Examples of these drugs are:

sodium bicarbonate
Acetazolamida

serotonergic drugs

Taking these drugs with lisdexamfetamine may increase your risk.serotonin syndrome, which can be deadly. If you are taking any of these medications, your doctor will start you on a lower dose of lisdexamfetamine and monitor you for signs of serotonin syndrome. Symptoms may include restlessness, sweating, muscle twitching, and confusion.

Examples of serotonergic drugs are:

selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine and sertraline
Serotonin and norepinephrine reuptake inhibitors (SNRIs) such as duloxetine and venlafaxine
TCAs such as amitriptyline and clomipramine
MAO inhibitors such as selegiline and phenelzine
the opioids fentanyl and tramadol
the anxiolytic buspirone
triptano
Lithium
tryptophan
juan herbs

Disclaimer:Our goal is to provide you with the most relevant and up-to-date information. However, because medications affect everyone differently, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always talk to your doctor about possible interactions with all prescription drugs, vitamins, herbs, dietary supplements, and over-the-counter drugs you are taking.

Lisdexamfetamine Warnings

This medication comes with several warnings.

allergy alert

Lisdexamfetamine can cause a severe allergic reaction. Symptoms may include:

acne
itch or hives
swelling of the face, lips, or tongue

If you develop these symptoms, call 911 or go to the nearest emergency room.

Do not take this medicine again if you have ever had an allergic reaction.Readministration could be fatal (cause death).

This medicine contains amphetamines. If you have an allergy or sensitivity to stimulants, tell your doctor before taking this medication.

Warnings for people with certain health problems

For people with heart problems:This medicine can cause a stroke, heart attack, or sudden death in adults with heart problems. It can cause sudden death in children and adolescents with pre-existing heart problems or defects. Tell your doctor if you have heart problems, heart defects, or a family history of these problems.

For people with blood pressure and heart rate problems:This medicine can increase your blood pressure and heart rate. Tell your doctor if you have problems with your blood pressure or heart rhythm. Your doctor will monitor you for these conditions.

For people with mental illness:If you have a mental illness, this medicine may make your symptoms worse. It can also cause psychotic or manic symptoms in children and adolescents with no history of these problems. Tell your doctor if you have a mental health problem or a family history of suicide, bipolar disorder, or depression. Call your doctor right away if you have new or worsening mental symptoms.

For people with a history of substance abuse and addiction:This drug can be abused and lead to addiction. Tell your doctor if you have ever abused or been dependent on alcohol or drugs.

Warnings for other groups

For pregnant women:This medicine may be harmful to the fetus. It should only be used during pregnancy if the potential benefit justifies the potential risk. Taking this medicine during pregnancy may increase your risk of having a premature baby or having a low birth weight. Tell your doctor if you are pregnant or plan to become pregnant.

For lactating women:This medicine can pass into breast milk and have serious effects on a nursing infant. Breast-feeding is not recommended during treatment with this medication.

For seniors:Older people may process this drug more slowly. Your doctor may start you on a lower dose to prevent too much of this medicine from building up in your body. This effect can be dangerous.

For children:For the treatment of ADHD, this medication has not been shown to be safe and effective for children under 6 years of age.

For the treatment of BED, this medication has not been shown to be safe and effective for use in children under 18 years of age.

Your child's growth will be monitored during treatment with this medicine. Children who do not grow or gain weight as expected may need to stop treatment.

How to take lisdexamfetamine

Not all possible dosages and forms can be included here. Its dose, form and frequency of taking will depend on:

your age
the disease to treat
how serious is your condition
other medical conditions you have
how do you react to the first dose

dosage form and concentrations

Brand:Wyvanse

Form:oral combing
Strengthen:10 mg, 20 mg, 30 mg, 40 mg, 50 mg, 60 mg, 70 mg

Dosage for Attention Deficit Hyperactivity Disorder (ADHD)

Adult dose (18 to 64 years)

Typical Starting Dose:30 mg taken once a day.
Typical dosage:30-70 mg taken once a day.
Maximum dose:70 mg pro label.
Dose adjustments:Your doctor may adjust your dose by 10 to 20 mg each week until you reach a dose that relieves your symptoms.

Dosage for children (6-17 years)

Typical Starting Dose:30 mg taken once a day.
Typical dosage:30-70 mg taken once a day.
Maximum dose:70 mg pro label.
Dose adjustments:Your doctor may adjust your child's dose by 10 to 20 mg each week until he reaches a dose that relieves his symptoms.

Dosage for children (0-5 years)

This medication should not be used in children under 6 years of age.

Dosage for seniors (65 years and older)

Your body may process this medicine more slowly. Your doctor may start you on a lower dose to prevent too much of this medicine from building up in your body. Too much drug can be dangerous.

Dosage for moderate to severe binge eating disorder (BED)

Adult dose (18 to 64 years)

Typical Starting Dose:30 mg taken once a day.
Typical dosage:50-70 mg taken once a day.
Maximum dose:70 mg pro label.
Dose adjustments:Your doctor may adjust your dose by 20mg per week up to a target dose of 50-70mg once a day.

Dosage for children (0-17 years)

This medication should not be used in children under 18 years of age.

Dosage for seniors (65 years and older)

Your body may process this medicine more slowly. Your doctor may start you on a lower dose to prevent too much of this medicine from building up in your body. Too much drug can be dangerous.

Special Dosage Instructions

If you have kidney disease:Your doctor may adjust your dose based on your kidney function:

Severe kidney disease:The maximum dose is 50 mg per day.
End-stage renal disease requiring dialysis:The maximum dose is 30 mg per day.

Disclaimer:Our goal is to provide you with the most relevant and up-to-date information. However, because drugs affect everyone differently, we cannot guarantee that this list includes all possible doses. This information is not a substitute for medical advice. Always talk to your doctor or pharmacist about the dose that is right for you.

take as directed

Lisdexamfetamine oral capsule is used for long-term treatment. It comes with serious risks if you don't take it as prescribed.

If you stop taking the medicine or stop taking it:If you stop taking this medicine suddenly, you may experience withdrawal symptoms. This is more likely if you have been taking a high dose for a long time. To avoid withdrawal, your doctor will slowly decrease your dose when you are ready to stop treatment.

If you do not take this medicine at all:Your symptoms will not be treated.

If you miss a dose or do not take the medicine on time:Your medicine may not work as well or may stop working altogether. For this medicine to work well, there must be a certain amount in your body at all times.

If you take too much:You could have dangerous levels of the drug in your body. Symptoms of an overdose of this medication may include:

concern
Shaking
confusion

If you think you have taken too much of this medication, call your doctor or seek advice from the American Association of Poison Control Centers at or through them at 800-222-1222.online tool.

But if your symptoms are severe, call 911 or go to the nearest emergency room right away.

What to do if you miss a dose:If you miss a dose, take it as soon as possible. However, if your next scheduled dose is only a few hours away, wait and take the single dose.

Never try to catch up by taking two doses at once. This can lead to dangerous side effects.

How to tell if the medicine is working:With ADHD, you should have a longer attention span and less impulsiveness and hyperactivity. For BED, you should have fewer binge days.

Important considerations when taking lisdexamfetamine

Keep these considerations in mind if your doctor prescribes lisdexamfetamine for you.

Generally

You can take this medicine with or without food.
Take this medicine once a day in the morning.
Do not cut or crush the oral capsule. Swallow the capsule whole.
You can open the capsule and pour the contents into yogurt, water, or orange juice. Be sure to empty all the powder out of the capsule to get the full dose. Eat or drink all of the yogurt, water, or orange juice right after you mix the medicine. Do not save it after you have mixed it with the medicine.

storage

Store this medicine at temperatures between 20°C and 25°C (68°F to 77°F).
Keep the medicine away from light.
Do not store this medication in damp or damp areas, such as bathrooms.
Store the medicine in a safe place, e.g. B. in a locked cabinet.
Do not throw away unused capsules with household waste. Ask your doctor or pharmacist about a drug take-back program in your community.

refills

A prescription for this medication is not refillable. You or your pharmacy will need to contact your doctor for a new prescription if you need to refill this medication.

Travel

If you travel with your medication:

Always carry your medicine with you. Never put it in checked baggage when you fly. Keep it in your hand luggage.
Don't worry about the X-ray machines at the airport. They cannot harm your medicine.
You may need to show the airport staff the pharmacy label for your medication. Always carry the original container marked with the prescription with you.
Do not put this medicine in the glove compartment of your car and do not leave it in the car. Avoid doing this at all costs when it is very hot or very cold.

Clinical Monitoring

To watch for possible side effects, your doctor may regularly monitor the following health problems:

blood pressure
heartbeat
Weight
mental health condition
height (in children)

To look for signs of abuse, your doctor may regularly monitor the following health problems:

heartbeat
respiratory rate
blood pressure
Weight
Look
mental health condition

Your doctor may also check your kidney function to make sure this medicine is safe for you.

Availability

Not all pharmacies sell this medicine. When you fill your prescription, be sure to call ahead to make sure your pharmacy has it.

priority authorization

Many insurance companies require prior approval for this drug. This means that your doctor must get approval from your health insurance company before your health insurance company will pay for the prescription.

Are there alternatives?

There are other medicines to treat your condition. Some may fit better than others. Talk to your doctor about other treatment options that may be right for you.

Disclaimer:Healthline has made every effort to ensure that all information is accurate, complete, and up-to-date. However, this article should not be used as a substitute for the knowledge and experience of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information in this document is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a particular drug does not mean that the drug or drug combination is safe, effective, or appropriate for all patients or for all specific uses.